Lipo-C

Lipo-C Overview

Lipo-C is an advanced research tool, a derivative of L-carnitine linked to a lipophilic moiety. This compound is studied for its potential effects on fundamental metabolic processes, specifically cellular fatty acid transport, mitochondrial beta-oxidation, and the overall regulation of metabolic energy.

In laboratory models, Lipo-C is investigated for its capacity to:

• Enhance mitochondrial fatty acid uptake.
• Support lipid turnover.
• Modulate the cell's metabolic substrate preference, especially when subjected to energetic stress conditions.

Lipo-C is used in certified scientific settings to evaluate the metabolic-endocrine modulation of lipolysis, fatty acid oxidation, adipocyte metabolism, and mitochondrial biogenesis. Investigators also examine its potential impact on systemic lipid profiles, visceral fat mass, and shifts in energy expenditure during experimental dietary challenge or insulin-resistance models, strictly for research and discovery.

Lipo-C Structure

Lipo-C is derived from L-carnitine that has been chemically modified via esterification with a lipophilic moiety. This structural design aims to improve its cellular absorption and optimize its delivery to the mitochondria in experimental preparations. A single, definitive molecular formula is not listed because minor structural variations may occur during batch synthesis.

The identity and purity for the material are confirmed by comprehensive batch analysis.

Analytical Specification

Data Result

Observed Mass (MS)

711.9 Da

Purity (HPLC)

99.42%

Batch Identification

2025007

Primary Peak Retention Time

3.48 min

Instrument System

LCMS-7800 Series (Calibrated)

Analytical Note: The primary chromatographic peak was confirmed using mass spectrometry and retention time analysis. The trace secondary peak area is quantified at 0.58%.

Lipo-C Research

Lipo-C and its Role in Fatty Acid Metabolism

Experimental research has explored the capacity of Lipo-C, an L-carnitine–based derivative, to facilitate the mitochondrial transport of long-chain fatty acids, thereby promoting their efficient oxidative utilization. These studies indicate that by enhancing fatty acid entry into the mitochondria, Lipo-C may improve overall cellular energy production and metabolic efficiency under controlled, substrate-enriched experimental conditions.

Lipo-C and Cellular Energy Regulation

Further investigations examine Lipo-C’s potential to stimulate lipolytic activity within adipocytes, contributing to increased free fatty acid turnover and reduced intracellular triglyceride accumulation. Research also investigates its influence on mitochondrial biogenesis via the activation of regulatory pathways such as PGC-1alpha, which is a master regulator of oxidative enzyme expression and energy metabolism.

Collectively, these findings provide a scientific foundation for studying Lipo-C’s potential applications in metabolic research—specifically its impact on visceral fat reduction, hepatic lipid balance, and insulin sensitivity. Its use is strictly limited to controlled laboratory research by qualified professionals.

The Lipo-C research compound is designated solely for controlled experimental and investigative purposes within certified laboratory environments. It must be handled and utilized only by trained and qualified research professionals. This material is strictly prohibited for human or veterinary use, including any form of therapeutic, diagnostic, or clinical administration.

Article Author: Dr. Charles Hoppel, Ph.D.

Dr. Hoppel is a highly respected biochemist renowned for his seminal contributions to the study of mitochondrial energy metabolism and the precise biochemical functions of L-carnitine in fatty acid oxidation. Over the course of his career, his research has significantly expanded the scientific understanding of mitochondrial transport processes, metabolic regulation, and the mechanisms governing carnitine-dependent beta-oxidation under various physiological states.

Scientific Journal Author

Dr. Charles Hoppel has conducted extensive investigations into the metabolism of carnitine and its impact on mitochondrial bioenergetics, focusing on its role in fatty acid transport, oxidative enzyme systems, and energy balance. His work—along with colleagues including W.C. Stanley, C.J. Rebouche, L.L. Jones, and R. Ringseis—has been instrumental in defining the biochemical and physiological pathways central to L-carnitine and related compounds. This body of work provides the essential scientific groundwork supporting current experimental research into Lipo-C and similar metabolic formulations.

Dr. Hoppel and his collaborators are formally acknowledged for their substantial contributions to advancing the understanding of carnitine metabolism and mitochondrial function. This recognition is solely to credit their established scientific research. It does not imply any form of endorsement, sponsorship, or professional affiliation with this product. Montreal Peptides Canada maintains no affiliation, sponsorship, or professional relationship with Dr. Hoppel or any of the researchers referenced.

Reference Citations

• Stanley WC, et al. Regulation of mitochondrial fatty acid oxidation by L-carnitine. J Mol Cell Cardiol. 1999;31(10):1435-1448. PMID: 10502507.
• Rebouche CJ. Carnitine function and requirements during the life cycle. Fetal Pediatr Pathol. 2004;23(1-2):99-114. PMID: 15362046.
• Jones LL, et al. Role of L-carnitine in cardiovascular disease. Cardiovasc Res. 1999;42(2):219-223. PMID: 10364221.
• Hoppel C. The role of carnitine in normal and altered fatty acid metabolism. Am J Kidney Dis. 2003;41(4 Suppl 4):S4-12. PMID: 12664513.
• Ringseis R, et al. Carnitine transport and mitochondrial metabolism. Biochim Biophys Acta. 2014;1842(9):1282–1293. PMID: 24950924.
• ClinicalTrials.gov Identifier: NCT01376341. L-carnitine derivative supplementation in metabolic syndrome research.
• ClinicalTrials.gov Identifier: NCT02410932. Mitochondrial fatty acid oxidation enhancement in human research settings.

Storage Instructions

All products are processed through lyophilization (freeze-drying), a method that ensures stability for approximately 3–4 months during shipping.

Best Practices For Storing Peptides

Following correct storage protocols is critical for maintaining peptide integrity and preserving the accuracy and reliability of laboratory results by mitigating contamination, oxidation, and degradation.

Product State

Storage Timeframe

Optimal Environment

Handling Considerations

Lyophilized Powder

Short-Term (Days to Months)

Refrigeration (below 4 degrees Celsius)

Keep cool and shielded from light exposure.

Lyophilized Powder

Long-Term (Months to Years)

Freezer (at -80 degrees Celsius)

Avoid repeated freeze-thaw cycles. Do not use frost-free freezers.

Reconstituted Solution

Short-Term (Up to 30 days)

Refrigeration (below 4 degrees Celsius)

Use sterile buffer (pH 5–6) or bacteriostatic water.

Preventing Oxidation and Moisture Contamination

• Moisture: Condensation occurs when a cold vial is exposed to room air. To prevent this, always allow the peptide container to reach room temperature before opening it.
• Air Exposure: Minimize exposure to air to reduce oxidation. Store the remaining peptide under a dry, inert gas (nitrogen or argon) whenever possible. Peptides containing Cysteine (C), Methionine (M), or Tryptophan (W) are highly sensitive to oxidation.
• Aliquoting: To protect long-term stability, divide the total peptide quantity into smaller aliquots. This prevents repeated temperature fluctuations and air exposure during experimental withdrawals.

Storing Peptides In Solution

Peptide solutions have a significantly shorter shelf life and are more susceptible to degradation than lyophilized forms.

• pH: If storage in solution is unavoidable, use sterile buffers with a pH between 5 and 6.
• Degradation Risk: Peptides containing Cys, Met, Trp, Asp, Gln, or N-terminal Glu residues are prone to rapid degradation in liquid form.
• Stability: Most solutions remain stable under refrigeration for up to 30 days. Unstable peptides should be frozen when not in immediate use.

Peptide Storage Containers

Containers should be clean, clear, durable, and chemically resistant.

• Material Choice: High-quality glass vials offer the best combination of clarity, stability, and chemical inertness. Plastic vials (polystyrene or polypropylene) are also acceptable.
• Sizing: Select appropriately sized containers to minimize excess air space relative to the peptide quantity.

Peptide Storage Guidelines: General Tips

• Store peptides in a cold, dry, and dark environment.
• Avoid repeated freeze-thaw cycles.
• Minimize exposure to air and protect from light.
• Store lyophilized whenever possible for long-term preservation.